Work

Profiles of Caregiver-Reported Executive Function in Children with Down Syndrome

Year: 2022

Type: article

Study design: Observational Study

Abstract: Children with Down syndrome (DS) are at risk for challenges with aspects of executive function (EF). The current study explores whether heterogeneity in EF profiles can be detected within a sample of children with DS. Participants were 69 children with DS, ages 3-10 years (M = 6.23, SD = 1.91). T-scores from a caregiver-report measure of executive function were modeled using latent profile analysis, and auxiliary analyses examined the association between demographic and biomedical factors and probability of profile membership. The two-profile solution was the best fit for the sample, with a profile that involved elevated scores in working memory only ("Working Memory Only" profile; 43% of sample) and a "Multi-Domain" profile that involved elevated scores in planning, inhibition, and working memory (57%). The presence of congenital heart defects was associated with a higher probability of assignment to the Multi-Domain profile. Findings from this study contribute to the characterization of heterogeneous outcomes associated with DS.

Source: Brain Sciences

DOI: 10.3390/brainsci12101333

Authors: Kaylyn Van Deusen, Mark A. Prince, Anna J. Esbensen, Jamie O. Edgin, Emily K. Schworer, Angela John Thurman, Lina R. Patel, Lisa A. Daunhauer, Deborah J. Fidler

Institutions: Colorado State University, Cincinnati Children's Hospital Medical Center, University of Cincinnati, University of Arizona, University of Wisconsin–Madison, University of California Davis Medical Center, UC Davis Health, University of California, Davis, University of Colorado Anschutz

Language: English

Topic: Down syndrome and intellectual disability research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,094

Funders: Georgia Clinical and Translational Science Alliance, National Institutes of Health, National Institute of Child Health and Human Development, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G169919855, G1705418431, Memory Measures for Clinical Trials in Down syndrome and Fragile X syndrome, G1859492571, G1869204958, G2660470558, G2683124041, G4292706323, G5936953203, G6874477042, G7095600115, G7448108406, G8085101257, Colorado Clinical and Transational Sciences Institute, Early risk for ADHD symptoms in young children with Down syndrome, Executive Function Outcome Measures for Young Children with Down Syndrome, G9000048651, G9000110373

OpenAlex ID: W4303613728

FWCI: 1.393

Cites: 65

Cited by: 9

Related to: 10