Year: 2022
Type: article
Abstract: We report a facile, transition metal-free synthesis of fluorobenzoic acids by nucleophilic fluorination of readily available 1-arylbenziodoxolones using fluoride salts in polar aprotic solvents.This protocol was applied for the preparation of 2-[ 18 F]-fluoro-5-nitrobenzoic acid, which is a potentially important radioligand for Positron Emission Tomography (PET).
Source: ARKIVOC
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: diamond
Funder: Russian Science Foundation
Award: G5122425998
OpenAlex ID: W4303673950