Design and Rationale for the Use of Magnetic Resonance Imaging Biomarkers to Predict Diabetes After Acute Pancreatitis in the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study
Year: 2022
Type: article
Study design: Study Protocol
Abstract: ABSTRACT: This core component of the Diabetes RElated to Acute pancreatitis and its Mechanisms (DREAM) study will examine the hypothesis that advanced magnetic resonance imaging (MRI) techniques can reflect underlying pathophysiologic changes and provide imaging biomarkers that predict diabetes mellitus (DM) after acute pancreatitis (AP). A subset of participants in the DREAM study will enroll and undergo serial MRI examinations using a specific research protocol. The aim of the study is to differentiate at-risk individuals from those who remain euglycemic by identifying parenchymal features after AP. Performing longitudinal MRI will enable us to observe and understand the natural history of post-AP DM. We will compare MRI parameters obtained by interrogating tissue properties in euglycemic, prediabetic, and incident diabetes subjects and correlate them with metabolic, genetic, and immunological phenotypes. Differentiating imaging parameters will be combined to develop a quantitative composite risk score. This composite risk score will potentially have the ability to monitor the risk of DM in clinical practice or trials. We will use artificial intelligence, specifically deep learning, algorithms to optimize the predictive ability of MRI. In addition to the research MRI, the DREAM study will also correlate clinical computed tomography and MRI scans with DM development.
Source: Pancreas
Authors: Temel Tirkes, Vernon M. Chinchilli, Ulas Bagci, Jason G. Parker, Xuandong Zhao, Anil K. Dasyam, Nicholas Feranec, Joseph R. Grajo, Zarine K. Shah, Peter D. Poullos, Benjamin Spilseth, Atif Zaheer, Karen L. Xie, Ashley M. Wachsman, Martha Campbell-Thompson, Darwin L. Conwell, Evan L. Fogel, Christopher E. Forsmark, Phil A. Hart, Stephen J. Pandol, Walter G. Park, Richard E. Pratley, Cemal Yazici, Maren R. Laughlin, Dana K. Andersen, Jose Serrano, Melena D. Bellin, Dhiraj Yadav
Institutions: Indiana University School of Medicine, Pennsylvania State University, Northwestern University, University of Pittsburgh Medical Center, AdventHealth Orlando, University of Florida, The Ohio State University Wexner Medical Center, The Ohio State University, University of Minnesota, Johns Hopkins University, Johns Hopkins Medicine, Johns Hopkins Hospital, University of Illinois Chicago, Cedars-Sinai Medical Center, Indiana University Hospital, Indiana University Indianapolis, Stanford Medicine, AdventHealth, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, University of Pittsburgh
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Understanding pancreatic endocrine and exocrine loss in pre-type 1 diabetes, Institutional Career Development, The function and regulation of the novel pregnancy-specific hexokinase HKDC1, Advanced 3T for Structural and Functional Imaging at University of Florida, Radiologist-Centered Artificial Intelligence (RCAI) for Lung Cancer Screening and Diagnosis, Immune Function and the Progression to Type 1 Diabetes, UPMC Clinical Center for the Study of Diabetes after Acute Pancreatitis, The Stanford Clinical Center for the Study of Type 1 Diabetes in Acute Pancreatitis, Epidemiology and Pathophysiology of Acute Pancreatitis-related Diabetes Mellitus, Cedars Sinai Clinical Center of the Type 1 Diabetes in Acute Pancreatitis Consortium, Type 1 Diabetes in Acute Pancreatitis Consortium – Pacific Northwest Clinical Center: Immune Pathogenesis of Post-Pancreatitis T1D, Cedars Sinai Center for the Chronic Pancreatitis Clinical Research Consortium, Mechanisms of diabetes from acute pancreatitis in African Americans and Hispanics, University of Minnesota Clinical Center for the Study of Acute Pancreatitis and Diabetes, The Chronic Pancreatitis Clinical Research Consortium, Data Coordinating Center for the Type 1 Diabetes in Acute Pancreatitis Consortium, Continuation of Type 1 Diabetes in Acute Pancreatitis Consortium – UF Health and AdventHealth Combined Clinical Center, Clinical, Radiologic and Biochemical Factors Related to Diabetes Development after Acute Pancreatitis, Indiana University clinical Center for acute pancreatitis and diabetes clinical research network
OpenAlex ID: W4303684895