Rationale and Design for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study
Year: 2022
Type: article
Study design: Study Protocol
Abstract: ABSTRACT: Acute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it is increasingly recognized as an important late and chronic complication. There are several challenges that have prevented precisely determining the incidence rate of DM after AP and understanding the underlying mechanisms. The DREAM (Diabetes RElated to Acute Pancreatitis and its Mechanisms) Study is a prospective cohort study designed to address these and other knowledge gaps to provide the evidence needed to screen for, prevent, and treat DM after AP. In the following article, we summarize literature regarding the epidemiology of DM after AP and provide the rationale and an overview of the DREAM study.
Source: Pancreas
Authors: Phil A. Hart, Georgios I. Papachristou, Walter G. Park, Anne-Marie Dyer, Vernon M. Chinchilli, Elham Afghani, Venkata S. Akshintala, Dana K. Andersen, James L. Buxbaum, Darwin L. Conwell, Kathleen M. Dungan, Jeffrey J. Easler, Evan L. Fogel, Carla J. Greenbaum, Rita R. Kalyani, Murray Korc, Richard Kozarek, Maren R. Laughlin, Peter J. Lee, Jennifer L. Maranki, Stephen J. Pandol, Anna Evans Phillips, Jose Serrano, Vikesh K. Singh, Cate Speake, Temel Tirkes, Frederico G.S. Toledo, Guru Trikudanathan, Santhi Swaroop Vege, Ming Wang, Cemal Yazici, Atif Zaheer, Christopher E. Forsmark, Melena D. Bellin, Dhiraj Yadav
Institutions: The Ohio State University Wexner Medical Center, The Ohio State University, Stanford Medicine, Stanford University, Pennsylvania State University, Johns Hopkins University, Johns Hopkins Medicine, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, University of Southern California, Indiana University School of Medicine, Benaroya Research Institute, University of California, Irvine, Penn State Milton S. Hershey Medical Center, Cedars-Sinai Medical Center, University of Pittsburgh, Indiana University Indianapolis, University of Pittsburgh Medical Center, University of Minnesota, Mayo Clinic, University of Illinois Chicago, Johns Hopkins Hospital, University of Florida
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1144150618, G2215772352, G2954712678, G3599581629, G5661771035, G5781043260, G7054456069, G70843923, G76741582, UPMC Clinical Center for the Study of Diabetes after Acute Pancreatitis, Cedars Sinai Clinical Center of the Type 1 Diabetes in Acute Pancreatitis Consortium, University of Minnesota Clinical Center for the Study of Acute Pancreatitis and Diabetes, Continuation of Type 1 Diabetes in Acute Pancreatitis Consortium – UF Health and AdventHealth Combined Clinical Center
OpenAlex ID: W4303684958