Work

A protein synthesis brake for hematopoietic stem cell maintenance

Year: 2022

Type: preprint

Abstract: Bmi1 is essential for normal and leukemic hematopoiesis, but its target genes in hematopoietic stem cells (HSCs) are incompletely understood. In this issue of Genes & Development, Burgess et al. (pp. 887–900) demonstrate a novel role of Bmi1 in regulating ribosome biogenesis and protein synthesis. Bmi1-deficient HSCs exhibited reduced transplantability, with the up-regulation of ARX and genes involved in ribosome biogenesis. However, depletion of ARX or its known targets, p16Ink4a/p19Arf, only partially rescues Bmi1 loss-induced hematopoietic defects. They further demonstrate an increased protein synthesis rate and resultant proteostatic stress in Bmi1−/− HSCs, indicating a novel mechanism by which Bmi1 controls HSC maintenance.

Source: Genes & Development

DOI: 10.1101/gad.350107.122

Authors: Kaosheng Lv, Wei Tong

Institutions: Southern University of Science and Technology, Children's Hospital of Philadelphia, University of Pennsylvania

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Southern University of Science and Technology, National Institutes of Health, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases