Assessing the Pathophysiology of Hyperglycemia in the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study
Year: 2022
Type: article
Study design: Study Protocol
Abstract: OBJECTIVES: The metabolic abnormalities that lead to diabetes mellitus (DM) after an episode of acute pancreatitis (AP) have not been extensively studied. This article describes the objectives, hypotheses, and methods of mechanistic studies of glucose metabolism that comprise secondary outcomes of the DREAM (Diabetes RElated to Acute pancreatitis and its Mechanisms) Study. METHODS: Three months after an index episode of AP, participants without preexisting DM will undergo baseline testing with an oral glucose tolerance test. Participants will be followed longitudinally in three subcohorts with distinct metabolic tests. In the first and largest subcohort, oral glucose tolerance tests will be repeated 12 months after AP and annually to assess changes in β-cell function, insulin secretion, and insulin sensitivity. In the second, mixed meal tolerance tests will be performed at 3 and 12 months, then annually, and following incident DM to assess incretin and pancreatic polypeptide responses. In the third, frequently sampled intravenous glucose tolerance tests will be performed at 3 months and 12 months to assess the first-phase insulin response and more precisely measure β-cell function and insulin sensitivity. CONCLUSIONS: The DREAM study will comprehensively assess the metabolic and endocrine changes that precede and lead to the development of DM after AP.
Source: Pancreas
Authors: Kathleen M. Dungan, Phil A. Hart, Dana K. Andersen, Marina Basina, Vernon M. Chinchilli, Kirstie K. Danielson, Carmella Evans-Molina, Mark O. Goodarzi, Carla J. Greenbaum, Rita R. Kalyani, Maren R. Laughlin, Ariana Pichardo-Lowden, Richard E. Pratley, Jose Serrano, Emily K. Sims, Cate Speake, Dhiraj Yadav, Melena D. Bellin, Frederico G. S. Toledo
Institutions: The Ohio State University Wexner Medical Center, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Stanford Medicine, Stanford University, Pennsylvania State University, University of Illinois Chicago, Indiana University School of Medicine, Cedars-Sinai Medical Center, Benaroya Research Institute, Johns Hopkins University, Johns Hopkins Medicine, Penn State Milton S. Hershey Medical Center, AdventHealth Orlando, AdventHealth, University of Pittsburgh
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: UPMC Clinical Center for the Study of Diabetes after Acute Pancreatitis, The Stanford Clinical Center for the Study of Type 1 Diabetes in Acute Pancreatitis, Epidemiology and Pathophysiology of Acute Pancreatitis-related Diabetes Mellitus, Cedars Sinai Clinical Center of the Type 1 Diabetes in Acute Pancreatitis Consortium, Type 1 Diabetes in Acute Pancreatitis Consortium – Pacific Northwest Clinical Center: Immune Pathogenesis of Post-Pancreatitis T1D, Mechanisms of diabetes from acute pancreatitis in African Americans and Hispanics, University of Minnesota Clinical Center for the Study of Acute Pancreatitis and Diabetes, Data Coordinating Center for the Type 1 Diabetes in Acute Pancreatitis Consortium, Continuation of Type 1 Diabetes in Acute Pancreatitis Consortium – UF Health and AdventHealth Combined Clinical Center, Clinical, Radiologic and Biochemical Factors Related to Diabetes Development after Acute Pancreatitis, Indiana University clinical Center for acute pancreatitis and diabetes clinical research network
OpenAlex ID: W4303685189