Year: 2022
Type: review
Abstract: The myristoylated alanine-rich C-kinase substrate (MARCKS) is a membrane-associated protein kinase C (PKC) substrate ubiquitously expressed in eukaryotic cells. MARCKS plays important roles in multiple cellular processes, including cell adhesion and motility, mucin secretion, exocytosis, and inflammatory response. Aberrant MARCKS signaling has been observed in the development and progression of multiple cancer types. In addition, MARCKS facilitates cancer metastasis through modulating cancer cell migration and invasion. Moreover, MARCKS contributes to treatment resistance, likely by promoting cancer stem cell renewal as well as immunosuppression. In this review, we describe MARCKS protein structure, cellular localization, and biological functions. We then discuss the role of MARCKS in cancer metastasis as well as its mechanisms of action in solid tumors. Finally, we review recent advances in targeting MARCKS as a new therapeutic strategy in cancer management.
Source: Cancers
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,513
Awards: G1082747127, G1515155708, Tackling the MARCKS-PIP3 Circuit to Attenuate Chronic Pulmonary Fibrosis, DETERMINING THE PREDICTIVE VALUE, FUNCTIONAL ROLE, AND MECHANISMS OF ACTION OF NUSAP1 IN CLEAR CELL RENAL CELL CARCINOMA, G3898232734, G4738782823, G6431957996, 1R43HL140740 - 01A1, Targeting AXL to overcome resistance to taxanes and platinum-based therapy in castrate resistant and neuroendocrine prostate cancer
OpenAlex ID: W4303685333