Human Cytomegalovirus Utilizes Multiple Viral Proteins to Regulate the Basement Membrane Protein Nidogen 1
Year: 2022
Type: article
Abstract: We have found that human cytomegalovirus (HCMV) utilizes multiple viral proteins in multiple pathways to regulate a ubiquitous cellular basement membrane protein, nidogen-1 (NID1). The extent of the resources and the redundant methods that the virus has evolved to affect this control strongly suggest that its removal provides a life cycle advantage to HCMV. Our discoveries that one of the proteins that HCMV uses to control NID1, pp71, binds directly to the cellular DNA and can exert control when present in vanishingly small quantities may have broad implications in a wide range of infection scenarios. Dysregulation of NID1 in an immunocompetent host is not known to manifest complications during infection; however, in the naive immune system of a developing fetus, disruption of this developmentally critical protein could initiate catastrophic HCMV-induced birth defects.
Source: Journal of Virology
DOI: 10.1128/jvi.01336-22
Institutions: University of Idaho, The Wistar Institute
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Chromosome 1 Damage in HCMV Infected Cells, Idaho INBRE Program, Repair of HCMV-Induced DNA Damage in Infected Cells, G4463571095, G4545511971, Center for Modeling Complex Interactions, G6850065706, HCMV infection downregulates nidogen 1 and myelin protein zero, Consolidated Basic Cancer Research Program, Regulation of Viral Chromatin Architecture During EBV Latency
OpenAlex ID: W4304191953