Year: 2022
Type: article
Abstract: Developing chemical tools to detect and influence biological processes is a cornerstone of chemical biology. Here we combine two tools which rely on orthogonality– perfluorocarbons and multiplexed shortwave infrared (SWIR) fluorescence imaging– to visualize nanoemulsions in real time in living mice. Drawing inspiration from fluorous and SWIR fluorophore development, we prepared two SWIR‐emissive, fluorous‐soluble chromenylium polymethine dyes. These are the most red‐shifted fluorous fluorophores– “fluorofluorophores”—to date. After characterizing the dyes, their utility was demonstrated by tracking perfluorocarbon nanoemulsion biodistribution in vivo . Using an excitation‐multiplexed approach to image two variables simultaneously, we gained insight into the importance of size and surfactant identity on biodistribution.
Institutions: University of California, Los Angeles, Texas A&M University
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
Funders: National Science Foundation, Welch Foundation, Tobacco-Related Disease Research Program, Chan Zuckerberg Initiative, National Institutes of Health, University of California, Los Angeles, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Biomedical Imaging and Bioengineering, Division of Chemistry
OpenAlex ID: W4310715703