Generation of two induced pluripotent stem cell lines from dilated cardiomyopathy patients carrying TTN mutations
Year: 2022
Type: article
Abstract: Dilated cardiomyopathy (DCM) is a common heart disease that can lead to heart failure and sudden cardiac death. Mutations in the TTN gene are the most frequent cause of DCM. Here, we generated two human induced pluripotent stem cell (iPSC) lines from the peripheral blood mononuclear cells (PBMCs) of two DCM patients carrying c.94816C>T and c.104188A>G mutations in TTN, respectively. The two lines exhibited a normal morphology, full expression of pluripotency markers, a normal karyotype and the ability of trilineage differentiation. The two lines can serve as useful tools for drug screening and mechanism studies on DCM.
Source: Stem Cell Research
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,100
Awards: G2168952822, G5170875372, Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology, Human iPSCs for Elucidating Intercellular Crosstalk Signaling in Dilated Cardiomyopathy, Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling, Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCs
OpenAlex ID: W4304891490