Year: 2023
Type: book-chapter
Abstract: The potential for evolutionary change is deeply anchored in the kind and amount of heritable phenotypic variation that organisms can produce, and thus in the way that ge ne tic predispositions translate into the phenotype.That translation is the genotype-phenotype (GP) map.We first explain the two common conceptualizations of GP map: the global correspondence map and the local mechanistic map, and how they relate to each other.We focus on the structural aspects of the GP mapping, as summarized in the notions of pleiotropy and epistasis, and argue that their effect on evolvability is not captured sufficiently in the current theory.One way to approach this prob lem is to address mechanistic, causal mapping explic itly and explore systematically the variational properties of vari ous well-known biochemical or regulatory pro cesses.This may allow us not only to better account for the effects of pleiotropy and epistasis, but also to potentially complement these summarizing concepts themselves with notions that better capture the under lying mechanisms-thus adding the mechanistic aspect to the global GP map.
Source: The MIT Press eBooks
Institution: Évolution, Génomes, Comportement, Écologie
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: hybrid
Funder: Norges Forskningsråd
Award: G8159394846
OpenAlex ID: W4305032650