Hydrogen Sulfide and Its Donors: Keys to Unlock the Chains of Nonalcoholic Fatty Liver Disease
Year: 2022
Type: article
Abstract: Hydrogen sulfide (H2S) has emerged as the third “gasotransmitters” and has a crucial function in the diversity of physiological functions in mammals. In particular, H2S is considered indispensable in preventing the development of liver inflammation in the case of excessive caloric ingestion. Note that the concentration of endogenous H2S was usually low, making it difficult to discern the precise biological functions. Therefore, exogenous delivery of H2S is conducive to probe the physiological and pathological roles of this gas in cellular and animal studies. In this review, the production and metabolic pathways of H2S in vivo, the types of donors currently used for H2S release, and study evidence of H2S improvement effects on nonalcoholic fatty liver disease are systematically introduced.
Authors: Xianghui Li, Kaixin Jiang, Yantian Ruan, Siyuan Zhao, Yiming Zhao, Yuhua He, Zhili Wang, Jiacun Wei, Qiming Li, Changyong Yang, Yanzhang Li, Tieshan Teng
Institution: Henan University
Language: English
Topic: Sulfur Compounds in Biology
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,408
Awards: G1297812272, G160981834, G167630235, G1889899235, G1944492132, G2287527039, G2936896052, G3072815113, G3478759950, G3676364561, G3694985771, G3721366277, G4632135732, G5382565681, G5675412773, G5728610851, G5872723001, G5895928303, G6138919888, G6141062452, G6240160152, G7198238550, G728456151, G7831598742, G8288405349, G8622780035, G977260511
OpenAlex ID: W4306152009