Year: 2022
Type: editorial
Abstract: The Research Topic, Insights in Striated Muscle Physiology: 2021, was focused on new insights, novel developments, current challenges, latest discoveries, recent advances and future perspectives in the field of Striated Muscle Physiology.The emphasis was on brief, forward-looking contributions highlighting recent developments and major accomplishments that have been achieved and target areas that need to be pursued to move striated muscle physiology forward.The hope is that this article collection will inspire, inform and provide direction and guidance to researchers in the field.The following is a synopsis of the articles in this Research Topic.The first article, to be published in this Research Topic, by Li et al., was focused on delineating differential mRNA and non-coding circular RNA (circRNA) expression in murine models of heart failure.This article provides highly valuable data to more completely understand the molecular profile of different stages of heart failure, including ventricular hypertrophy and heart failure with preserved or reduced ejection fraction.The results reveal how various stages of heart failure differ with respect to gene expression and this, in turn, is expected to promote the development of testable hypotheses to further investigate altered mechanistic underpinnings of compromised cardiac function as heart failure progresses.While the presence of circRNAs in viruses was discovered almost 50 years ago (Hsu et al., 1974), then in eukaryotes shortly thereafter (Hsu and Coca-Prados, 1979), the roles that they have in normal organ function and in pathophysiology are not well understood.The review article by Huang and Janssen highlights the many advantages and disadvantages of using human tissues to investigate mechanisms related to cardiovascular disease.Consideration of variables, such as tissue/organ procurement appropriate for the experimental design, paucity of available control samples, comorbidities and drug treatment history, is of paramount importance when working with human samples.The authors specifically focus on myocardial protein phosphorylation which is an integral consequence of beta-adrenergic stimulation and results in augmented cardiac force generation and rates of contraction and relaxation.
Source: Frontiers in Physiology
Authors: Peter J. Reiser, Paul M. L. Janssen
Institution: The Ohio State University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,950
OpenAlex ID: W4306163750