Work

Involvement of 27-hydroxycholesterol on the progression of non-small cell lung cancer via the estrogen receptor.

Year: 2022

Type: article

Abstract: genes, were significantly increased in the tumor tissues. In cultured H23 cells, proliferation was significantly increased by 27HC and E2 treatments for 48 h. Similar to breast cancer, the present results supported idea that the 27HC produced from alveolar macrophages promotes the proliferation of lung cancer cells highly expressing ER through the SERM action. Therefore, 27HC should be an important target for cancer therapy of NSCLC.

Source: PubMed Central

Authors: Ikki Takada, Teruo Miyazaki, Yushi Goto, Hiroya Kanzawa, Taisuke Matsubara, Haruka Namikawa-Kanai, Shunsuke Shigefuku, Shotaro Ono, Eiji Nakajima, Yukio Morishita, Akira Honda, Kinya Furukawa, Norihiko Ikeda

Institutions: Tokyo Medical University, Tokyo Medical University Ibaraki Medical Center

Language: English

Topic: Cancer, Lipids, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4306168006

FWCI: 0.528

Cites: 45

Cited by: 6

Related to: 10