Ectopic clotting factor VIII expression and misfolding in hepatocytes as a cause for hepatocellular carcinoma
Work
Year: 2022
Type: article
Abstract: Hemophilia A gene therapy targets hepatocytes to express B domain deleted (BDD) clotting factor VIII (FVIII) to permit viral encapsidation. Since BDD is prone to misfolding in the endoplasmic reticulu... more
Source: Molecular Therapy
Institutions McGill University Health Centre, Discovery Institute, University of California, San Diego, University of Michigan, Cornell University +4 more
Cites: 69
Cited by: 20
Related to: 10
FWCI: 2.198
Citation percentile (by year/subfield): 100
Subfield: Molecular Biology
Domain: Life Sciences
Sustainable Development Goal Good health and well-being
Open Access status: hybrid
APC paid (est): $3,900
Funders National Institutes of Health, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Diabetes and Digestive and Kidney Diseases
Grant IDS DK113171, CA198103, 1P01HL160472-01, P30DK 120515