Year: 2022
Type: review
Abstract: Traditionally majority of eukaryotic gene expression is influenced by transcriptional and post-transcriptional events. Alterations in the expression of proteins that act post-transcriptionally can affect cellular signaling and homeostasis. RNA binding proteins (RBPs) are a family of proteins that specifically bind to RNAs and are involved in post-transcriptional regulation of gene expression and important cellular processes such as cell differentiation and metabolism. Deregulation of RNA-RBP interactions and any changes in RBP expression or function can lead to various diseases including cancer. In cancer cells, RBPs play an important role in regulating the expression of tumor suppressors and oncoproteins involved in various cell-signaling pathways. Several RBPs such as HuR, AUF1, RBM38, LIN28, RBM24, tristetrapolin family and Musashi play critical roles in various types of cancers and their aberrant expression in cancer cells makes them an attractive therapeutic target for cancer treatment. In this review we provide an overview of i). RBPs involved in cancer progression and their mechanism of action ii). the role of RBPs, including HuR, in breast cancer progression and DNA damage response and iii). explore RBPs with emphasis on HuR as therapeutic target for breast cancer therapy.
Source: Advanced Drug Delivery Reviews
Language: English
Topic: RNA Research and Splicing
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $5,150
Funders: U.S. Department of Veterans Affairs, Presbyterian Health Foundation, University of Oklahoma, Tobacco Settlement Endowment Trust, National Institutes of Health, University of Oklahoma Health Sciences Center, Stephenson Cancer Center, National Cancer Institute, National Institute of General Medical Sciences
Awards: G1181589793, G285398573, Mentoring Translational Cancer Research in Oklahoma, G501766673, An improved IL-24 gene-based therapeutic for cancer, HuR Targeted Nanotherapy for Lung Cancer, G854442891, G9000049281, G9000264061, Exosomes as carriers of cancer therapeutics, Stephenson Cancer Center - Cancer Center Support Grant
OpenAlex ID: W4306181562