Year: 2022
Type: review
Abstract: A major challenge in engineering scalable three-dimensional tissues is the generation of a functional and developed microvascular network for adequate perfusion of oxygen and growth factors. Current biological approaches to creating vascularized tissues include the use of vascular cells, soluble factors, and instructive biomaterials. Angiogenesis and the subsequent generation of a functional vascular bed within engineered tissues has gained attention and is actively being studied through combinations of physical and chemical signals, specifically through the presentation of topographical growth factor signals. The spatiotemporal control of angiogenic signals can generate vascular networks in large and dense engineered tissues. This review highlights the developments and studies in the spatiotemporal control of these biological approaches through the coordinated orchestration of angiogenic factors, differentiation of vascular cells, and microfabrication of complex vascular networks. Fabrication strategies to achieve spatiotemporal control of vascularization involves the incorporation or encapsulation of growth factors, topographical engineering approaches, and 3D bioprinting techniques. In this article, we highlight the vascularization of engineered tissues, with a focus on vascularized cardiac patches that are clinically scalable for myocardial repair. Finally, we discuss the present challenges for successful clinical translation of engineered tissues and biomaterials.
Source: Bioengineering
Authors: Astha Khanna, Beu P. Oropeza, Ngan F. Huang
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,780
Awards: G1017354501, iPSC-Derived Smooth Muscle Progenitors in Elastin Hydrogels for Treating Abdominal Aortic Aneurysm, G1533673325, Aligned Nanofibrillar Scaffolds Enhance Angiogenesis and Viability in Ischemia, Substrate Stiffness Modulates Endothelial-to-Mesenchymal Transition, G3344434360, G3531976141, Engineered matrix microarrays to enhance the regenerative potential of iPSC-derived endothelial cells, G4274433966, G4404059840, G4586000846, G5792377579, G5899376848, G6946849956, ISS: Tissue Engineered Muscle in Microgravity as a Novel Platform to Study Sarcopenia, G8195136211, G8854749559, G8960295015, G8961076480, G992070739
OpenAlex ID: W4306362348