Association of citrulline concentration at birth with lower respiratory tract infection in infancy: Findings from a multi-site birth cohort study
Year: 2022
Type: article
Study design: Observational Study
Abstract: Assessing the association of the newborn metabolic state with severity of subsequent respiratory tract infection may provide important insights on infection pathogenesis. In this multi-site birth cohort study, we identified newborn metabolites associated with lower respiratory tract infection (LRTI) in the first year of life in a discovery cohort and assessed for replication in two independent cohorts. Increased citrulline concentration was associated with decreased odds of LRTI (discovery cohort: aOR 0.83 [95% CI 0.70–0.99], p = 0.04; replication cohorts: aOR 0.58 [95% CI 0.28–1.22], p = 0.15). While our findings require further replication and investigation of mechanisms of action, they identify a novel target for LRTI prevention and treatment.
Source: Frontiers in Pediatrics
Authors: Brittney M. Snyder, Tebeb Gebretsadik, Kedir N. Turi, Christopher McKennan, Suzanne Havstad, Daniel J. Jackson, Carole Ober, Susan Lynch, Kathryn McCauley, Christine M. Seroogy, Edward M. Zoratti, Gurjit K. Khurana Hershey, Sergejs Berdnikovs, Gary Cunningham, Marshall L. Summar, James E. Gern, Tina V. Hartert, on behalf of the ECHO-CREW investigators
Institutions: Vanderbilt University, Vanderbilt University Medical Center, University of Pittsburgh, Henry Ford Health, University of Wisconsin–Madison, University of Chicago, University of California, San Francisco, Henry Ford Hospital, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Northwestern University, Children's National
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
Funders: U.S. Department of Health and Human Services, Vanderbilt University, Emory University, Michigan Department of Health and Human Services, Vanderbilt University Medical Center, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases
Awards: Wisconsin Infant Study Cohort (WISC) ECHO Pediatric Follow-Up, G1680326333, G243193170, G4397165329, G6498627102, Microbiota and Allergic Asthma Precision Prevention (MAAP2), G8436211625, G9000001166, G9000042721, G9000101658, G9000119642, G9000122439, G9000132204, G9000142362, G9000145354, G9000148510, G9000196150, G9000206832, G9000318298, G9000330424
OpenAlex ID: W4306385498