Editorial: Structure, isotypes, targets, and post-translational modifications of immunoglobulins and their role in infection, inflammation and autoimmunity, Volume II
Year: 2022
Type: editorial
Abstract: Structure, isotypes, targets, and post-translational modifications of immunoglobulins and their role in infection, inflammation and autoimmunity Volume II Post-translational modifications, isotypes, and the antigen/epitope specificity of immunoglobulins are shaped by inflammatory processes and impacted by the genetic background of the host (1-8).These factors contribute to how infection, autoimmunity, and cancer are resolved or, conversely, how autoimmune processes and cancer may progress.The humoral responses, i.e., antibody production, is influenced by the metabolism of plasma cells but also by the isotype of immunoglobulins, composition of their variable segments (variable heavy-chain and variable light-chain sequences), and post-translational modifications (predominantly glycosylation).The activities of antibodies further depend on the expression of corresponding receptors on various cell types.These receptors are Fc receptors (specific for Fc portions of IgG, IgA, IgM, or IgE) and Fc receptor-like molecules (e.g., receptors specific for IgG immune complexes, IgA immune complexes, polymeric IgA, secretory IgA).Thus, affinity of antibodies to antigens and autoantigens is determined predominantly by the variable regions, avidity is determined by the isotype, whereas the sum of effector functions of the antibodies is shaped by relative amounts of different isotypes, their post-translational modifications, and the corresponding receptors on different cells.
Source: Frontiers in Immunology
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
OpenAlex ID: W4306399355