Year: 2022
Type: editorial
Abstract: Lineage tracing, hematopoietic stem cell and immune cell dynamicsLineage tracing has enabled intimate insights into cellular relationships and dynamics of developing blood and immune cells, their homeostasis and regeneration, and dysregulation in disease (1).By revealing where and when cells originate and following the fate of (individual) cells, lineage tracing has advanced our understanding of differentiation, cell fate, malignant transformation, and adaptive responses to environmental cues.In light of advances in single cell multi-omics, we summarize new directions enabled by works from this Research Topic.Penter et al. review tools for the high-resolution monitoring of disease evolution, focusing on naturally occurring genetic alterations for in vivo lineage tracing in human clinical specimens.For example, immune cell receptor V(D)J rearrangements of T cell and B cell receptors have long served to investigate clonal dynamics, heterogeneity, and responses of the immune system in disease settings.To study clonal dynamics and phylogenetically dissect subclones in malignancies, chromosomal copy number variants have been invaluable (2), given their relative ease of detection via single cell sequencing.By contrast, the de novo detection of single nucleotide variants in the nuclear genome of individual cells is more challenging.Still, these variants are often directly linked to altered Frontiers in Immunology frontiersin.
Source: Frontiers in Immunology
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,950
OpenAlex ID: W4306684271