Postdiagnosis recreational physical activity and breast cancer prognosis: Global Cancer Update Programme ( CUP Global) systematic literature review and meta‐analysis
Year: 2022
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: It is important to clarify the associations between modifiable lifestyle factors such as physical activity and breast cancer prognosis to enable the development of evidence-based survivorship recommendations. We performed a systematic review and meta-analyses to summarise the evidence on the relationship between postbreast cancer diagnosis physical activity and mortality, recurrence and second primary cancers. We searched PubMed and Embase through 31st October 2021 and included 20 observational studies and three follow-up observational analyses of patients enrolled in clinical trials. In linear dose-response meta-analysis of the observational studies, each 10-unit increase in metabolic equivalent of task (MET)-h/week higher recreational physical activity was associated with 15% and 14% lower risk of all-cause (95% confidence interval [CI]: 8%-22%, studies = 12, deaths = 3670) and breast cancer-specific mortality (95% CI: 4%-23%, studies = 11, deaths = 1632), respectively. Recreational physical activity was not associated with breast cancer recurrence (HR = 0.97, 95% CI: 0.91-1.05, studies = 6, deaths = 1705). Nonlinear dose-response meta-analyses indicated 48% lower all-cause and 38% lower breast cancer-specific mortality with increasing recreational physical activity up to 20 MET-h/week, but little further reduction in risk at higher levels. Predefined subgroup analyses across strata of body mass index, hormone receptors, adjustment for confounders, number of deaths, menopause and physical activity intensities were consistent in direction and magnitude to the main analyses. Considering the methodological limitations of the included studies, the independent Expert Panel concluded 'limited-suggestive' likelihood of causality for an association between recreational physical activity and lower risk of all-cause and breast cancer-specific mortality.
Source: International Journal of Cancer
DOI: 10.1002/ijc.34324
Authors: Margarita Cariolou, Leila Abar, Dagfinn Aune, Katia Balducci, Nerea Becerra‐Tomás, Darren C. Greenwood, Georgios Markozannes, Neesha Nanu, Rita Vieira, Edward L. Giovannucci, Marc J. Gunter, Alan A. Jackson, Ellen Kampman, Vivien Lund, Kate Allen, Nigel T. Brockton, Helen Croker, Daphne Katsikioti, Deirdre McGinley‐Gieser, Panagiota Mitrou, Martin Wiseman, Amanda J. Cross, Elio Riboli, Steven K. Clinton, Anne McTiernan, Teresa Norat, Konstantinos K. Tsilidis, Doris S. M. Chan
Institutions: Imperial College London, Oslo University Hospital, Karolinska Institutet, Oslo Nye Høyskole, University of Leeds, University of Ioannina, Harvard University, Centre international de recherche sur le cancer, National Institute for Health and Care Research, University of Southampton, Wageningen University & Research, World Cancer Research Fund International, American Institute for Cancer Research, The Ohio State University, Fred Hutch Cancer Center
Language: English
Topic: Cancer Risks and Factors
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,700
Funders: Breast Cancer Research Foundation, World Health Organization, Ohio State University, University of Dundee, World Cancer Research Fund International, Cancer Research UK, University of Southampton, Newcastle University, University of Leeds, Wereld Kanker Onderzoek Fonds, Comprehensive Cancer Center, University of Alabama at Birmingham, World Cancer Research Fund, Wageningen University and Research
OpenAlex ID: W4307186912