Work

Editorial: Genetic basis of tolerance induction defects underlying the development of autoimmune pathologies

Year: 2022

Type: editorial

Abstract: Genetic basis of tolerance induction defects underlying the development of autoimmune pathologiesIn our initial call for review articles for the Research Topic "Genetic Basis of Tolerance Induction Defects Underlying the Development of Autoimmune Pathologies" we envisioned four areas of interest for this Research Topic: Area 1 -the genetic basis for tolerance induction defects underlying any single or multiple autoimmune disease states; Area 2 -the controversy concerning how well some animal models, in particular mice, inform the basis of various autoimmune pathologies in humans; Area 3 -how gene variants disrupt Treg/Breg development or activity resulting in autoimmune disease states; and Area 4 -genes x environment interactions contributing to various autoimmune states.For anyone involved in autoimmunity research, it is not surprising to find the usual suspects in the three review articles that fall under Area 1 of this Topic: MHCs/HLAs, PTPN22, PTPN2, CTLA4, IFIH1 etc.The editors are grateful to the contributing authors for presenting these common players from differing perspectives using both overlapping and unique sources.Here, we would like to call out discussed allelic variants unique to each of the reviews.Kissler's "Genetic Modifiers of Thymic Selection and Central Tolerance in Type 1 Diabetes" presents a section on TAGAP which may be of interest for those studying thymic migration of developing T-cells.Hocking and Buckner's "Genetic basis of defects in immune tolerance underlying the development of autoimmunity" presents a section on PADI2 and PADI4 variants in rheumatoid arthritis (RA).PADI2 and PADI4 are enzymes responsible for the conversion of arginine to citrulline.Recent work has indicated that post translational modifications Frontiers in Immunology frontiersin.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2022.1069232

Authors: Jeremy J. Racine, Laurence Morel, Yi-Guang Chen, David V. Serreze

Institutions: Jackson Laboratory, The University of Texas at San Antonio Health Science Center, Medical College of Wisconsin

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950