Sex and age-dependent changes of the cerebral cortex in young adult Sudanese: A brain segmentation study
Year: 2022
Type: article
Study design: Observational Study
Abstract: The present study aimed to measure the cortical structures of cerebral hemispheres, including cortical thickness (CT), grey and white matter volume (GMV and WMV) and volume fraction (GMVF and WMVF), in addition to the volume (V) and cortical area pial (CAP) in normal young adult Sudanese and to investigate the effect of sex and age on these cortical structures.The study included 139 healthy young adult Sudanese subjects (80 males and 59 females).Participants' ages ranged from 20-40 years.T1-weighted MR brain images with a thickness of 1 mm were obtained.MR images of the subjects were analyzed using the automatic segmentation software (BrainSuite).Cortical structures of the cerebral hemispheres were estimated using the output data of the process of the software.Sex differences were noticed in the GMV (325.76±38.74cm 3 ), WMV (182.09±26.70cm 3 ), V (507.85±62.20cm 3 ), and CAP (1263.22±127.42cm 2 ) of the cerebral hemisphere (P<0.05).However, there were no differences between genders in CT (3.81±0.17mm),GMVF (64.20±1.98%),and WMVF (35.80±1.98%) of the cerebral hemisphere (P>0.05).Changes with age were seen in the GMV, GMVF, WMVF, and CAP of the cerebral hemisphere (P<0.05).However, there were no changes with age in CT, WMV, and V of the cerebral hemisphere (P>0.05).Sex and age are important factors to consider when evaluating the cortical structures of the cerebral hemisphere.Sex affects GMV, WMV, V, and CAP, but not on the CT, WMVF, and GMVF.Age affects GMV, CAP, WMVF, and GMVF, but not on the CT, V, and WMV.
Authors: Wegdan AHMED, Tahir OSMAN, Bünyamin ŞAHİN, Samy AHMED, Amani ELFAKI
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4307422315