Cancer screening and breast cancer family history in Spanish-speaking Hispanic/Latina women in California
Year: 2022
Type: article
Study design: Observational Study
Abstract: Background: . Women with pathogenic variants in these genes have a 40-80% lifetime risk of breast cancer. Past studies have shown that genetic counseling can help women and their families make informed decisions about genetic testing and early cancer detection or risk-reduction strategies. However, H/L are 3.9-4.8 times less likely to undergo genetic testing than NHW women. We developed a program to outreach and educate the H/L community about hereditary breast cancer, targeting monolingual Spanish-speaking individuals in California. Through this program, we have assessed cancer screening behavior and identified women who might benefit from genetic counseling in a population that is usually excluded from cancer research and care. Materials and Methods: The "Tu Historia Cuenta" program is a promotores-based virtual outreach and education program including the cities of San Francisco, Sacramento, and Los Angeles. Participants responded to three surveys: a demographic survey, a breast cancer family history survey, and a feedback survey. Survey responses were described for participants and compared by area where the program took place using chi-square, Fisher exact tests, and t tests. Multinomial logistic regression models were used for multivariate analyses. Results and Conclusion: We enrolled 1042 women, 892 completed the cancer family history survey and 62 (7%) provided responses compatible with referral to genetic counseling. We identified 272 women (42.8% ages 40 to 74 years) who were due for mammograms, 250 women (24.7% ages 25 to 65 years) due for Papanicolaou test, and 189 women (71.6% ages 50+) due for colorectal cancer screening. These results highlight the need of additional support for programs that spread awareness about cancer risk and facilitate access to resources, specifically within the H/L community.
Source: Frontiers in Oncology
Authors: Lizeth I. Tamayo, Fabian Perez, Angelica Perez, Miriam Hernandez, Alejandra Martinez, Xiaosong Huang, Valentina A. Zavala, Elad Ziv, Susan L. Neuhausen, Luis G. Carvajal-Carmona, Ysabel Duron, Laura Fejerman
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,950
Awards: G1653290266, Biological implications of breast cancer protective variants in Latin Americanwomen with high Indigenous American ancestry, G2060608610, G3872136526, Genetic studies of homologous recombination deficiency in hispanic gastric cancer, G7043167852, University of California Minority Patient-Derived Xenograft (PDX) Development and Trial Center (UCaMP) to Reduce Cancer Health Disparities, UC Davis Clinical and Translational Science Center, Cancer Center Support Grant P30
OpenAlex ID: W4307556313