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Associations Among Sex, Cognitive Ability, and Autism Symptoms in Individuals with Down Syndrome

Year: 2022
Type: article
Study design: Observational Study
Abstract: This study explores sex-differences in (a) rates and profiles of autism symptoms as well as in (b) the contribution of intellectual quotient (IQ) to autism symptom presentation in Down syndrome (DS). Participants were 40 males and 38 females with DS, aged 6 to 23 years. Autism symptoms were rated through the Autism Diagnostic Observation Schedule-Second Edition (ADOS-2). Results show no sex differences in the ADOS-2 Calibrated Severity Scores (CSS). However, only females with DS who are classified as DS-Only have higher scores on verbal IQ than those classified as DS + autism. Furthermore, associations between IQ and all CSSs are found for females, but not for males. Findings suggest that verbal cognition may play differential roles for females and males with DS.
DOI: 10.1007/s10803-022-05779-6
Authors: Laura del Hoyo Soriano, Audra Sterling, Jamie Edgin, Debra R. Hamilton, Elizabeth Berry-Kravis, Amanda Dimachkie Nunnally, Angela John Thurman, Leonard Abbeduto
Institutions: University of California Davis Medical Center, UC Davis Health, University of California, Davis, University of Wisconsin–Madison, University of Arizona, Emory University, Rush University Medical Center
Language: English
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $2,890
Awards: G145855662, G156123175, G1859492571, G2719456613, Interdisciplinary Training for Autism Researchers, G9000025022, G9000044775, G9000048651, G9000118999
OpenAlex ID: W4307779272
FWCI: 0.995
Cites: 57
Cited by: 5
Related to: 10