A Novel Ex Vivo Drug Assay for Assessing the Transmission-Blocking Activity of Compounds on Field-Isolated Plasmodium falciparum Gametocytes
Year: 2022
Type: article
Abstract: The discovery and development of transmission-blocking therapies challenge malaria elimination and necessitate standard and reproducible bioassays to measure the blocking properties of antimalarial drugs and candidate compounds. Most of the current bioassays evaluating the transmission-blocking activity of compounds rely on laboratory-adapted Plasmodium strains.
DOI: 10.1128/aac.01001-22
Authors: Dinkorma T. Ouologuem, Laurent Dembele, Antoine Dara, Aminatou K. Kone, Nouhoum Diallo, Cheick P. O. Sangare, Fatoumata I. Ballo, François Dao, Siaka Goita, Aboubecrin S. Haidara, Aliou Traore, Amadou B. Niangaly, Souleymane Dama, Sekou Sissoko, Fanta Sogore, Jacob N. Dara, Yacouba N. Barre, Amadou Daou, Fatoumata Cisse, Ousmaila Diakite, Diagassan Doumbia, Sekou Koumare, Bakary Fofana, Fatalmoudou Tandina, Daman Sylla, Adama Sacko, Mamadou Coulibaly, Mamadou M. Tekete, Amed Ouattara, Abdoulaye A. Djimde
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4307923091