A Review of On the Psychobiological Differences among Tetrahydrocannabinol, Cannabinol, Cannabidiol and Cannabigerol
Year: 2022
Type: article
Abstract: The endocannabinoid system plays a physiological natural anti-inflammatory anticancer role and the pharmacological effects of cannabinoids from Cannabis plant simply reflect the action of the endogenous ones. Therefore, from a therapeutic point of view Cannabis plant cannot be understood without taking into consideration the physio-pathological role of the endocannabinoid system. Despite the great number of potentially therapeutic molecules with the Cannabis plant, they may be synthetized within four archetypic molecules, which consist of tetra-hydro-cannabinol (THC), cannabinol (CBN), cannabigerol (CBG) and cannabidiol (CBD). All molecules play a similar anticancer activity, whereas their psychological effects are different. THC is the only psychotropic sychedelic cannabinoid, whereas the other three cannabinoids have no psychotropic effect, but exert an important anxiolytic activity. Moreover, only THC acts as a direct enzyme responsible for annabinoid degradation, by enhancing the endogenous cannabinoid content. Unfortunately, despite the great number of experimental studies, the clinical use of cannabinoids in the treatment of systemic human diseases is still at the beginning.
Source: Clinical Reviews & Cases
Authors: Giusy Messina, Franco Rovelli, Paolo Lissoni
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4308005827