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Microneedle Patches Loaded with Nanovesicles for Glucose Transporter-Mediated Insulin Delivery

Year: 2022
Type: article
Abstract: Glucose-responsive insulin delivery systems that mimic insulin secretion activity in the pancreas show great potential to improve clinical therapeutic outcomes for people with type 1 and advanced type 2 diabetes. Here, we report a glucose-responsive insulin delivery microneedle (MN) array patch that is loaded with red blood cell (RBC) vesicles or liposome nanoparticles containing glucose transporters (GLUTs) bound with glucosamine-modified insulin (Glu-Insulin). In hyperglycemic conditions, high concentrations of glucose in interstitial fluid can replace Glu-Insulin via a competitive interaction with GLUT, leading to a quick release of Glu-Insulin and subsequent regulation of blood glucose (BG) levels in vivo . To prolong the effective glucose-responsive insulin release from MNs, additional free Glu-Insulin, which serves as “stored insulin”, is loaded after RBC vesicles or liposome nanoparticles bound with Glu-Insulin. In the streptozotocin (STZ)-induced type 1 diabetic mouse model, this smart GLUT-based insulin patch can effectively control BG levels without causing hypoglycemia.
Source: ACS Nano
DOI: 10.1021/acsnano.2c05687
Authors: Qian Chen, Zhisheng Xiao, Chao Wang, Guojun Chen, Yuqi Zhang, Xudong Zhang, Xiao Han, Jinqiang Wang, Xiao Ye, Mark R. Prausnitz, Song Li, Zhen Gu
Institutions: University of North Carolina at Chapel Hill, North Carolina State University, California NanoSystems Institute, University of California, Los Angeles, Soochow University, Lampe Joint Department of Biomedical Engineering, Zhejiang University, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Georgia Institute of Technology, Sir Run Run Shaw Hospital
Language: English
Open Access status: green
Funders: National Science Foundation, American Diabetes Association, North Carolina State University, National Institutes of Health, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: G1209820108, Bio-Inspired Synthetic Pathway for Closed-Loop Delivery of Insulin and Glucagon, G3130742632, NNCI: North Carolina Research Triangle Nanotechnology Network (RTNN), Platelets-Mediated Delivery of Checkpoint Inhibitors for Post-Surgical Cancer Immunotherapy, G7681175737, G9000074368, G9000096417
OpenAlex ID: W4308053633
FWCI: 6.346
Cites: 43
Cited by: 95
Related to: 10