Year: 2022
Type: article
Abstract: Dear Editor,Pneumonia infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appeared in Wuhan in December 2019.The World Health Organization (WHO) officially named it coronavirus disease 2019 (COVID-19).SARS-CoV-2 binds to host cells via the angiotensin receptor (ACE) 2 (ACE2R).The expression of ACE2R is particularly high in the lungs, heart, veins and arteries, and hematopoietic stem cells (1).A range of clinical manifestations is accompanied with COVID-19, including fever, dry cough, pulmonary involvement, and coagulopathy.One of the most important clinical manifestations of COVID-19 disease is cytokine storm, which can lead to systemic inflammation and multiple organ failure.Accordingly, it is clear that the prognosis of the disease has been influenced by multiple organ dysfunctions.Older age and comorbidities such as cardiovascular disease (CVD) have been the most common risk factors for the severity and mortality of the COVID-19 infection (2).According to the Centers for Disease Control and Prevention, the probability of hospitalization increases with age so that adults over 65 years old have a 3-to 15fold increased chance of being hospitalized due to this infection.In addition, the chance of death in COVID-19 patients over 65 years old is 90-630 times higher (3).The effect of COVID-19 on the hematopoietic system can be deduced from hematologic manifestations such as lymphopenia and thrombocytopenia, which are highly common in hospitalized COVID-19 patients.It was shown that COVID-19 affects the hematopoietic system and inhibits hematopoiesis through the induction of apoptosis in hematopoietic stem cells or the activation of inflammatory signaling pathways (4, 5).In recent data, the COVID-19 infection has been reported to be involved in the damage of hematopoietic stem cells through activating nucleotide-binding domain leucine-rich repeat protein-3 inflammasome (5).
Source: Disease and Diagnosis
DOI: 10.34172/ddj.2022.32
Institution: Hormozgan University of Medical Sciences
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4308118201