Work

Contra-thermodynamic halolactonization of lactam-tethered 5-aryl-4( E )-pentenoic acids for the flexible and stereocontrolled synthesis of fused lactam-halolactones

Year: 2022

Type: article

Abstract: -methylmorpholine oxide as the catalyst. The lactam-lactone products are synthesized in high diastereoselectivity, modularity, and chemoselectivity. Notably, most of the bicycles contain one benzylic quaternary stereocenter as well as an α-alkoxy quaternary stereocenter.

Source: RSC Advances

DOI: 10.1039/d2ra04177d

Authors: Timothy K. Beng, Claire Borg, Morgan J. Rodriguez

Institution: Central Washington University

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,042

Funder: Central Washington University