Year: 2022
Type: editorial
Abstract: The role of immune cells in hepatic ischemia reperfusionWe are honored to accept twelve articles on the Research Topic of "The role of immune cells in hepatic ischemia-reperfusion," which have received widespread interest.Hepatic ischemia-reperfusion (I/R) injury is a pathological process involved in oxidative stress-induced cellular damage and immune activation during liver resection and transplantation.We have known that the generation of reactive oxygen species (ROS) from oxidative stress may be critical mediators during hepatic IR.However, there is growing interest in the roles of immune cells in IR-triggered liver inflammation and injury.Liver resection and transplantation are the most effective treatments for patients with hepatocellular carcinoma.However, there is still a high recurrence rate after surgery, of which liver IR injury is closely related to liver cancer recurrence.Immune activation is crucial in the inflammatory damage process of liver I/R.The intense and sustained inflammatory response promotes tumor recurrence by activating tumor cell proliferation, adhesion, invasion, angiogenesis, and immune escape by many key inflammatory components.Targeting critical immune and inflammatory signaling pathways reduces I/ R-induced liver inflammation and injury and prevents tumor recurrence after liver surgery, suggesting a promising win-win strategy (Chen et al.).The severity of I/R injury in the liver is primarily determined by the ratio of M1 to M2 macrophages.Hepatic I/R injury triggers the release of Damage-associated molecular patterns (DAMPs) that strongly activate the NLRP3 inflammasome.This essential molecule functions as a critical component of the innate immune response in hepatic macrophages.Increasing autophagy in
Source: Frontiers in Immunology
Authors: Bibo Ke, Helong Dai, Qiang Wei, Zhiyong Guo, Tao Qiu
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
OpenAlex ID: W4308352591