Work

Copper-Catalyzed Decarboxylative Elimination of Carboxylic Acids to Alkenes

Year: 2022

Type: preprint

Abstract: A copper-catalyzed decarboxylative elimination reaction of (hetero)aromatic propionic acids to vinyl (hetero)arenes has been developed. This method furnishes alkenes from carboxylic acids without the need for stochiometric Pb or Ag additives or expensive or specialized photocatalysts. A series of mechanistic experiments indicate that the reaction proceeds via benzylic deprotonation and subsequent radical decarboxylation; a pathway that is distinct from the single-electron-transfer mechanisms implicated in related decarboxylative elimination reactions.

Source: ChemRxiv

DOI: 10.26434/chemrxiv-2022-lxc1v

Authors: Michael Stanton, Jessica Hoover

Institution: West Virginia University

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Science Foundation, West Virginia University, Division of Chemistry