The influence of three-dimensional structure on naïve T cell homeostasis and aging
Year: 2022
Type: article
Abstract: A breakdown in cellular homeostasis is thought to drive naïve T cell aging, however the link between naïve T cell homeostasis and aging in humans is poorly understood. To better address this, we developed a lymphoid organoid system that maintains resting naïve T cells for more than 2 weeks, in conjunction with high CD45RA expression. Deep phenotypic characterization of naïve T cells across age identified reduced CD45RA density as a hallmark of aging. A conversion from CD45RAhighnaive cells to a CD45RAlowphenotype was reproduced within our organoid system by structural breakdown, but not by stromal cell aging or reduced lymphocyte density, and mediated by alternative CD45 splicing. Together, these data suggest that external influences within the lymph node microenvironment may cause phenotypic conversion of naïve T cells in older adults.
Source: Frontiers in Aging
Authors: Simon Lambert, Wenqiang Cao, Huimin Zhang, Alex Colville, Jie-Yu Liu, Cornelia M. Weyand, Jorg J. Goronzy, Claire E. Gustafson
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,900
Awards: G1108740576, Dysregulation of Naïve T cell Quiescence during Aging, G1809139246, G2305232878, G366100091, Oligoclonal T Cell Expansion and Rheumatoid Arthritis, G6241365711, G9000017482, G9000107322, G9000126294, G9000137488, G9000150726, G9000269492, The NOTCH Signaling Pathway in Large Vessel Vasculitis, Vaccine and Infection Induced Immunity in the Young and Aged
OpenAlex ID: W4308450976