Work

Aurora A phosphorylates Ndel1 to reduce the levels of Mad1 and NuMA at spindle poles

Year: 2022

Type: article

Abstract: extracts. Our data suggest that dynein/SAC complexes that are generated at kinetochores and then transported directionally toward poles on microtubules are inhibited by Aurora A before they reach spindle poles. These data suggest that Aurora A generates a spatial signal at spindle poles that controls dynein transport and spindle function.

Source: Molecular Biology of the Cell

DOI: 10.1091/mbc.e21-09-0438

Authors: Paweł Ł. Janczyk, Eliza Żyłkiewicz, Henry De Hoyos, Thomas West, Daniel R. Matson, Won-Chan Choi, Heather M. Raimer Young, Zygmunt S. Derewenda, P. Todd Stukenberg

Institution: University of Virginia

Language: English

Topic: Microtubule and mitosis dynamics

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Cancer Institute, National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke

Awards: Mechanisms to move and steer chromosomes, Molecular Mechanisms of Neuronal Migrations, Training in Cell and Molecular Biology, Mechanisms of mitotic regulation, University of Virginia Cancer Center Support Grant

OpenAlex ID: W4308639323

FWCI: 0.401

Cites: 59

Cited by: 3

Related to: 10