Work

Portable mass spectrometry system: instrumentation, applications, and path to ‘omics analysis

Year: 2022

Type: review

Abstract: Mass spectrometry (MS) is an information rich analytical technique and plays a key role in various 'omics studies. Standard mass spectrometers are bulky and operate at high vacuum, which hinder their adoption by the broader community and utility in field applications. Developing portable mass spectrometers can significantly expand the application scope and user groups of MS analysis. This review discusses the basics and recent advancements in the development of key components of portable mass spectrometers including ionization source, mass analyzer, detector, and vacuum system. Further, major areas where portable mass spectrometers are applied are also discussed. Finally, a perspective on the further development of portable mass spectrometers including the potential benefits for 'omics analysis is provided.

Source: PROTEOMICS

DOI: 10.1002/pmic.202200112

Authors: Jing Wang, Madison E. Pursell, Amanda DeVor, Olanrewaju Awoyemi, Stephen J. Valentine, Peng Li

Institution: West Virginia University

Language: English

Topic: Mass Spectrometry Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Science Foundation, National Institute of General Medical Sciences, Division of Electrical, Communications and Cyber Systems

Awards: Development of VSSI-probe technology for in situ probing biological systems using mass spectrometry, CAREER: Compact digital biosensing system enabled by localized acoustic streaming, G3460122762, G8328675941