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Bioavailability and Pharmacokinetics of Endoxifen in Female Rats and Dogs: Evidence to Support the Use of Endoxifen to Overcome the Limitations of CYP2D6-Mediated Tamoxifen Metabolism

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Year: 2022
Type: article
Source: Drug Metabolism and Disposition
DOI: 10.1124/dmd.122.000929
Authors: Emily J. Koubek, Sarah A. Buhrow, Stephanie L. Safgren, Lee Jia, Matthew P. Goetz, Matthew M. Ames, Joel M. Reid
Institutions: National Institutes of Health, Mayo Clinic
Language: English

Topic: Pharmacogenetics and Drug Metabolism
Subfield: Pharmacology
Field: Pharmacology, Toxicology and Pharmaceutics
Domain: Life Sciences
SDG: Good health and well-being

Open Access status: green

Funders: Eli Lilly and Company, Pfizer, AstraZeneca, National Institutes of Health, National Cancer Institute
Awards: G131523128, G3503792436, G386607036, G4630458729, G5888954722, G5920237370, Preclinical Pharmacological Studies of Antitumor and Other Therapeutic Agents, G844520391, G9000126810, Mayo Clinic Comprehensive Cancer Center Support Grant
OpenAlex ID: W4308686531
FWCI: 0.913
Cites: 41
Cited by: 4
Related to: 10
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