Work

Cytokine Pathways in Cardiac Dysfunction following Burn Injury and Changes in Genome Expression

Year: 2022

Type: review

Abstract: In 2016, an estimated 486,000 individuals sustained burn injuries requiring medical attention. Severe burn injuries lead to a persistent, hyperinflammatory response that may last up to 2 years. The persistent release of inflammatory mediators contributes to end-organ dysfunction and changes in genome expression. Burn-induced cardiac dysfunction may lead to heart failure and changes in cardiac remodeling. Cytokines promote the inflammatory cascade and promulgate mechanisms resulting in cardiac dysfunction. Here, we review the mechanisms by which TNFα, IL-1 beta, IL-6, and IL-10 cause cardiac dysfunction in post-burn injuries. We additionally review changes in the cytokine transcriptome caused by inflammation and burn injuries.

Source: Journal of Personalized Medicine

DOI: 10.3390/jpm12111876

Authors: Jana E. DeJesus, Jake J. Wen, Ravi Radhakrishnan

Institution: The University of Texas Medical Branch at Galveston

Language: English

Topic: Burn Injury Management and Outcomes

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,094