Work

Synthesis of push–pull-activated ynol ethers and their evaluation in the bioorthogonal hydroamination reaction

Year: 2022

Type: article

Abstract: in methanol, but it proved too unstable toward thiols. These fluorinated ynol ethers further demonstrate the importance of the hyperconjugation-rehybridization effect in activating alkynes and demonstrate how substituent effects can both activate and stabilize alkynes for bioorthogonal reactivity.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/d2ob01917e

Authors: Dahye Kang, Conrad Wahl, Justin Kim

Institutions: Harvard University, Dana-Farber Cancer Institute

Language: English

Topic: Click Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of Environmental Health Sciences

Award: Post-Translational Modification of Protein Surfaces