Longitudinal neighbourhood determinants with cognitive health and dementia disparities: protocol of the Multi-Ethnic Study of Atherosclerosis Neighborhoods and Aging prospective cohort study
Year: 2022
Type: article
Study design: Study Protocol
Abstract: INTRODUCTION: The burden of Alzheimer's disease (AD) and AD-related dementias (ADRD) is increasing nationally and globally, with disproportionate impacts on lower-income, lower education and systematically marginalised older adults. Presence of inequalities in neighbourhood factors (eg, social context, physical and built environments) may affect risk of cognitive decline and be key for intervening on AD/ADRD disparities at the population level. However, existing studies are limited by a dearth of longitudinal, detailed neighbourhood measures linked to rich, prospective cohort data. Our main objective is to identify patterns of neighbourhood change related to prevalence of-and disparities in-cognitive decline and dementia. METHODS AND ANALYSES: We describe the process of collecting, processing and linking extensive neighbourhood data to the Multi-Ethnic Study of Atherosclerosis (MESA), creating a 25+ years dataset. Within the MESA parent study, the MESA Neighborhoods and Aging cohort study will characterise dynamic, longitudinal neighbourhood social and built environment variables relevant to cognition for residential addresses of MESA participants. This includes administering new surveys, expanding residential address histories, calculating new measures derived from spatial data and implementing novel deep learning algorithms on street-level imagery. Applying novel statistical techniques, we will examine associations of neighbourhood environmental characteristics with cognition and clinically relevant AD/ADRD outcomes. We will investigate determinants of disparities in outcomes by socioeconomic position and race/ethnicity and assess the contribution of neighbourhood environments to these disparities. This project will provide new evidence about pathways between neighbourhood environments and cognitive outcomes, with implications for policies to support healthy ageing. ETHICS AND DISSEMINATION: This project was approved by the University of Washington and Drexel University Institutional Review Boards (protocols #00009029 and #00014523, and #180900605). Data will be distributed through the MESA Coordinating Center. Findings will be disseminated in peer-reviewed scientific journals, briefs, presentations and on the participant website.
Source: BMJ Open
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,839
Awards: Built Environment Assessment through Computer visiON (BEACON): Applying Deep Learning to Street-Level and Satellite Images to Estimate Built Environment Effects on Cardiovascular Health, The Macrovascular and Microvascular Contributions to Alzheimer's Disease: MESA VASCAD, G1156594538, G1261793039, MESA, G1276754516, G1409423729, G1483344193, G1497137905, G1508998135, G1640378483, G1686417863, Neurodegenerative diseases and the role of green space: A deep learning assessment, Wake Forest Alzheimer's Disease Core Center, G1922428914, G2144938473, G22458031, G2262782284, MESA, G2545476352, MESA, G2837638605, G283874107, G290884426, G291913881, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READING, G3093995152, G3106377335, Atrial fibrillation burden, vascular disease of the brain and cardiac MRI in MESA, G3312077471, G3581052147, G3647016462, G3667269547, G3687594596, MESA, G3990748671, G399481048, TITLE: MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA), G4401650913, G4512137732, OPTION 3. 4/1/2014 - 3/31/2015. MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA) - READING CENTER, NHLBI, MESA, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-ULTRASOUND, Neighborhoods and Cardiovascular Risk in a Multiethnic Cohort, G5605591545, G5654179670, G5787256936, G6095866717, G611940047, G6359107525, Institute for Clinical and Translational Research, MESA, G6514094751, G66341962, G7003760051, G713258703, MESA, G78770644, Neurodegenerative diseases and the role of green space: A deep learning assessment, G805458286, Clinical and Translational Science Award, G9000004549, G9000004784, G9000006353, G9000017360, G9000019818, G9000025517, G9000063950, G9000065698, Subclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD (Renewal), Contribution of Longitudinal Neighborhood Determinants to Cognitive Health and Dementia Disparities within a Multi-Ethnic Cohort, Alzheimer's Disease Research Center, G926863539, G991334795
OpenAlex ID: W4308805677