Intraerythrocytic and Intralymphocytic Glutathion Peroxidase Enzyme Activities in Patients with Brucellosis
Year: 2001
Type: article
Study design: Observational Study
Abstract: In this study, the activities of intraerythrocytic and intralymphocytic glutathion peroxidase enzymes (GSH-Px) were determined in 60 patients with brucella infection. There were 4 groups, each containing 20 individuals. In group I (20 patients) enzyme activities were measured before treatment, in group II (20 patients) during treatment and in group III (20 patients) after treatment. Group IV (20 people) served as control group and included healthy individuals. The intraerythrocytic GSH-Px activity was 95.07 ± 16.57, 99.95 ± 16.63, 118.42 ± 33.72, and 128.03 ± 39.53 U/g haemoglobin in groups I to IV, respectively. The intralymphocytic GSH-Px activity was 742.02 ± 14.32, 681.08 ± 9.12, 545.86 ± 8.30, and 558.09 ± 11.73 U/mg protein in groups I to IV, respectively. The GSH-Px activity in erythrocytes were lower in all groups when compared to the control group, there was a statistically significant difference between the patient and the control groups (p< 0.05). The intralymphocytic GSH-Px activities were higher except group III in all groups when compared to the control group. The difference in groups I and II was statistically significant (p< 0.05) except treated group (group III). In conclusion, intraerythrocytic GSH-Px enzyme activities were lower in all patients with brucellosis, and intralymphocytic GSH-Px enzyme activities were higher in all cases. The intralymphocytic GSH-Px plays an important role in both the immune response to brucellosis and the response to the treatment.
Institutions: Inonu University, Kadir Has University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4308856988