Year: 2022
Type: article
Abstract: Maternal polyunsaturated fatty acids and allergic disease development in the offspringTo the Editor, The increasing global prevalence of allergic diseases makes it imperative to identify modifiable risk factors for allergic disease development.Maternal antenatal plasma fatty acid composition has been proposed as a risk factor of infant allergic disease.1,2 Polyunsaturated fatty acids (PUFAs) are key components of cell membranes and influence immune cell function by regulating membrane fluidity, intracellular signaling, and gene expression.3 They can be classified into n-3 and n-6 PUFAs, which are linked to production of anti-inflammatory and pro-inflammatory molecules, respectively.3 The fetoplacental unit lacks the desaturase enzymes required to synthesize long chain PUFAs so that, during pregnancy, the fetus is dependent on transplacental supply of PUFAs from the mother.
Source: Pediatric Allergy and Immunology
DOI: 10.1111/pai.13876
Authors: Ruyu Li, Hui Xing Lau, Qai Ven Yap, Yiong Huak Chan, Elizabeth Huiwen Tham, Anne Eng Neo Goh, Hugo Van Bever, Johan Gunnar Eriksson, Shiao‐Yng Chan, Kok Hian Tan, Yap Seng Chong, Bee Wah Lee, Lynette Pei‐chi Shek, Fabian Kok Peng Yap, Philip C. Calder, Keith M. Godfrey, Mary Foong‐Fong Chong, Evelyn Xiu Ling Loo
Institutions: Agency for Science, Technology and Research, Singapore Institute for Clinical Sciences, National University of Singapore, National University Hospital, National University Health System, KK Women's and Children's Hospital, University of Helsinki, Folkhälsans Forskningscentrum, Nanyang Technological University, Duke-NUS Medical School, University Hospital Southampton NHS Foundation Trust, NIHR Southampton Biomedical Research Centre, University of Southampton, MRC Lifecourse Epidemiology Unit
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,900
Funders: Danone, National Institute for Health and Care Research, British Heart Foundation, European Commission, National Research Foundation, Agency for Science, Technology and Research, Singapore Institute for Clinical Sciences, National Research Foundation Singapore, National University Health System, National Institute for Health Research Southampton Biomedical Research Centre, Medical Research Council, National Medical Research Council, Erasmus+
Awards: G1917706474, G1956390128, G2368920978, G2701677525, G2780654756, G3210728687, G3424013768, NIHR Senior Investigator Award, G3778457340, G3873828540, G427574963, NIHR Senior Investigator Award, G5224105001, G524590474, G5755632036, G606602278, G6206044308, G6907919727, G7388601084, G7852524164, G8346907872, Nutrition, Development and Lifelong Health: Studies in European Populations
OpenAlex ID: W4308916845