Work

PI(4,5)P2: signaling the plasma membrane

Year: 2022

Type: article

Abstract: In the almost 70 years since the first hints of its existence, the phosphoinositide, phosphatidyl-D-myo-inositol 4,5-bisphosphate has been found to be central in the biological regulation of plasma membrane (PM) function. Here, we provide an overview of the signaling, transport and structural roles the lipid plays at the cell surface in animal cells. These include being substrate for second messenger generation, direct modulation of receptors, control of membrane traffic, regulation of ion channels and transporters, and modulation of the cytoskeleton and cell polarity. We conclude by re-evaluating PI(4,5)P2's designation as a signaling molecule, instead proposing a cofactor role, enabling PM-selective function for many proteins.

Source: Biochemical Journal

DOI: 10.1042/bcj20220445

Authors: Rachel C. Wills, Gerald R. V. Hammond

Institution: University of Pittsburgh

Language: English

Topic: Cellular transport and secretion

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: National Cancer Institute, National Institute of General Medical Sciences

Award: Directing Membrane Function with Inositol Lipids in Health and Disease