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Clonally related composite chronic lymphocytic leukaemia and mantle cell lymphoma

Year: 2022
Type: article
Abstract: chronic lymphocytic leukemia; clonal haematopoiesis; composite lymphoma; mantle cell lymphoma Chronic lymphocytic leukaemia (CLL) is the most common adult leukaemia in the Western world, accounting for 25% of adult leukaemias.Morphologically, CLL cells are small with clumped chromatin and scant cytoplasm.Immunophenotypically, CLL cells are monotypic B cells that express CD5, CD19, CD20(dim), and CD23.Mantle cell lymphoma (MCL), accounting for 6% of all non-Hodgkin B-cell lymphomas (NHL), is usually associated with a more aggressive disease course compared with CLL.Morphologically, MCL cells are heterogeneous with a diffuse, nodular, or mantle zone growth pattern in the tissue or leukaemic phase.In some cases, MCL cells are pleomorphic or blastoid, while in
DOI: 10.1111/bjh.18565
Authors: Qianze Dong, Yang Wang, Yan Xiu, Hany Sakr, Bettina Burnworth, Dongbin Xu, Timothy O'Brien, Juanita Burke, Shimin Hu, Gang Zeng, Chen Zhao
Institutions: Case Western Reserve University, Louis Stokes Cleveland VA Medical Center, The University of Texas MD Anderson Cancer Center, Mayo Clinic, University Hospitals of Cleveland, University Hospitals Cleveland Medical Center
Language: English
Subfield: Genetics
Field: Medicine
Open Access status: green
OpenAlex ID: W4308945970
FWCI: 0.254
Cites: 17
Cited by: 2
Related to: 10