Work

Mucosal Infection with Unmasked Candida albicans Cells Impacts Disease Progression in a Host Niche-Specific Manner

Year: 2022

Type: article

Abstract: Shielding the immunogenic cell wall epitope β(1, 3)-glucan under an outer layer of mannosylated glycoproteins is an essential virulence factor deployed by Candida albicans during systemic infection. Accordingly, mutants with increased β(1, 3)-glucan exposure (unmasking) display increased immunostimulatory capabilitiesin vitroand attenuated virulence during systemic infection in mice.

Source: Infection and Immunity

DOI: 10.1128/iai.00342-22