Work

Association of blood cadmium and metabolic syndrome: a cross-sectional analysis of National Health and Nutrition Examination Survey 2017–2020

Year: 2022

Type: article

Abstract: Previous findings have reported the role of different types of heavy metals in cardiometabolic diseases. In the present research, we aim to evaluate the association between blood cadmium levels and MetS base on the large-sample NHANES data. Public availably data from NHANES 2017–2020 cycle was obtained. Participants were divided into MetS and non-MetS groups according to waist circumference (WC), triglyceride (TG), high-density lipoprotein (HDL), blood pressure (BP) and fasting plasma glucose (FPG) levels based on the National Cholesterol Education Program (NCEP) criteria. Student’s t test, Mann-Whitney U test, and Chi-square test were performed for univariate analysis. Multivariate logistic analysis was performed to explore the relationship between blood cadmium and MetS and research findings were presented in forest plot. We also investigated the association of blood cadmium and MetS in subgroups stratified by age, gender and race. Population with MetS had significantly higher levels of blood cadmium compared with those without MetS [0.30 (0.18–0.54) vs. 0.24 (0.15–0.46) ug/L, p < 0.001]. Higher blood cadmium concentrations were also observed in participants with elevated WC, TG, BP and FPG compared with those with normal metabolic parameters. Multivariate logistic regression showed that one unit increasement of blood cadmium was associated with 1.25 times higher prevalence ratios for MetS after adjusting potential confounders (95% CI: 1.06–1.48, p = 0.0083). Stratified multiple logistic regression analysis indicated that the positive association between blood cadmium and MetS remained significant in subjects less than 60 years old and female subgroup. In conclusion, the cross-sectional survey suggested the positive association between blood cadmium levels and risk for MetS, prospective research need to be conducted for further evaluation of the causal relationship between blood cadmium and MetS.

Source: Environmental Science and Pollution Research

DOI: 10.1007/s11356-022-24177-0