Work

Shikonin impedes type 2 ovarian cancer progression via FasL/caspase-8 and mir-874-3p/XIAP axis and prohibits the properties of stemness.

Year: 2022

Type: article

Abstract: ) expressions, sphere formation assay was executed and a xenograft animal model for in vivo antitumor effects of SHK. Taken together, Shikonin suppressed type 2 ovarian cancer cell viability, migration, and invasion abilities; decreased CSC-related markers expression as well as the sphere colony numbers. It also reduced the tumorigenicity of KURAMOCHI ALDH+ cells and induced anti-tumor effect in a xenograft model. Thus, SHK could contribute a potential therapeutic strategy on type 2 ovarian cancer cells via multiple functions.

Source: PubMed Central

Authors: Yu-Hsun Chang, Yu-Jung Lin, Chih-Yang Huang, Tomor Harnod, Dah-Ching Ding

Institutions: Tzu Chi University, Tzu Chi Foundation, Asia University, China Medical University, China Medical University Hospital, Hualien Tzu Chi Medical Center

Language: English

Topic: Bioactive Compounds and Antitumor Agents

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4309245313

FWCI: 1.62

Cites: 46

Cited by: 11

Related to: 10