Work

Light-driven biocatalytic oxidation

Year: 2022

Type: review

Abstract: , monooxygenases, peroxygenases, oxidases, or dehydrogenases) catalyze a variety of enantioselective oxyfunctionalization and dehydrogenation reactions under mild conditions. To sustain the catalytic cycles of these enzymes, constant supply with or withdrawal of reducing equivalents (electrons) is required. Being redox by nature, photocatalysis appears a 'natural choice' to accomplish the electron-relay role, and many photoenzymatic oxidation reactions have been developed in the past years. In this contribution, we critically summarize the current developments in photoredoxbiocatalysis, highlight some promising concepts but also discuss the current limitations.

Source: Chemical Science

DOI: 10.1039/d2sc03483b

Authors: Chul-Ho Yun, Jinhyun Kim, Frank Hollmann, Chan Beum Park

Institutions: Chonnam National University, Korea Advanced Institute of Science and Technology, Delft University of Technology

Language: English

Topic: Enzyme Catalysis and Immobilization

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funders: National Research Foundation, National Research Foundation of Korea