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JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRAS G12C for the Treatment of Solid Tumors

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Year: 2022
Type: article
Source: Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.2c01438
Authors: Edwige Lorthiois, Marc Gerspacher, Kim S. Beyer, Andrea Vaupel, Catherine Leblanc, Rowan Stringer, Andreas Weiss, Rainer Wilcken, Daniel A. Guthy, Andreas Lingel, Claudio Bomio-Confaglia, Rainer Machauer, Pascal Rigollier, Johannes Ottl, Dorothee Arz, Pascal Bernet, Gaëlle Desjonqueres, Solene Dussauge, Malika Kazic-Legueux, Marie-Anne Lozac’h, Christophe Mura, Mickaël Sorge, Milen Todorov, Nicolas Warin, Florence Zink, Hans Voshol, Frederic J. Zecri, Richard C. Sedrani, Nils Ostermann, Saskia M. Brachmann, Simona Cotesta
Institutions: Novartis (Switzerland), Novartis Institutes for BioMedical Research
Language: English

Topic: Protein Kinase Regulation and GTPase Signaling
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
SDG: Good health and well-being

Open Access status: closed

Funder: Novartis Pharmaceuticals Corporation
OpenAlex ID: W4309368997
FWCI: 6.304
Cites: 36
Cited by: 112
Related to: 10
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