Year: 2022
Type: article
Abstract: Photo-mediated Ultrasound Therapy (PUT), as a new anti-vascular technique, can promote cavitation activity to selectively destruct blood vessels with a significantly lower amount of energy when compared to energy level required by other laser and ultrasound treatment therapies individually. Here, we report the development of a high speed PUT system based on a 50-kHz pulsed laser to achieve faster treatment, decreasing the treatment time by a factor of 20. Furthermore, we integrated it with optical coherence tomography angiography (OCTA) for real time monitoring. The feasibility of the proposed OCTA-guided PUT was validated through in vivo rabbit experiments. The addition of OCTA to PUT allows for quantitative prescreening and real time monitoring of treatment response, thereby enabling implementation of individualized treatment strategies.
Source: Scientific Reports
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,190
Awards: In vivo Imaging and Quantification of Cilia Beating Dynamics Using Phase-Resolved Optical Imaging Technology, G1523888516, High-resolution Elastographic Assessment of the Optic Nerve Head, G36446433, Comprehensive Atherosclerotic Plaque Evaluation using Integrated Intravascular Ultrasound and Polarization-Sensitive OCT, Continuous Monitoring and Management of Vaginal Health via Multifunctional OCT/OCTA Endoscopy, G560498944, G5729145195, Combined OCT/US/PAT system for intravascular Imaging, Phase resolved ARF optical coherence elastography for intravascular imaging
OpenAlex ID: W4309563837