Work

The "Janus-like" RNA-editing machinery in innate antiviral immunity.

Year: 2022

Type: article

Abstract: R has been linked to the pathology of several human mental conditions, such as Schizophrenia, anxiety, bipolar disorder, major depression, and the mental illnesses of substance use disorders (SUD). Thus, the ADAR-1-mediated RNA editing may be either beneficial or harmful; these effects need to be tightly modulated to sustain innate antiviral immunity while restricting undesired off-target self-reactivity. In this communication, we discuss ideas and tools to identify the orphan drug candidates, including small molecules and biologics that may serve as effective modulators of the ADAR-1/IFN innate immunity and are thereby promising for use in treating or preventing SUD- and/or viral infection-associated mental illnesses.

Source: PubMed

Authors: Lisa Wu, Denong Wang

Institution: SRI International

Language: English

Topic: RNA regulation and disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute on Drug Abuse, National Cancer Institute

Awards: ADAR1-Mediated HIV RNA Modifications, Oligomannose antigens as conserved immunological targets of Non-Hodgkin lymphomas